Professor Austin explores four main areas in this paper. First of all he outlines the physical development of sex differentiation in the embryo. He develops this by describing the clinical manifestations of abnormality which can appear at that stage. Professor Austin points out that there are relatively few people with abnormalities and that those who do show homosexual tendencies are not noticeably different from the norm in terms of their sexual equipment and hormone levels. It is much more (...) likely that their psychological and social development has a greater influence in differentiating them sexually. The last section of the paper is a synopsis of society's reactions to homosexuality or bisexuality which term in Professor Austin's opinion is more accurate and descriptive of the condition. (shrink)

This study reports on the preliminary outcome evaluation of the Magone Home Aftercare Program (MHAP), a faith-based juvenile justice residential facility in the Philippines that provides intensive aftercare treatment for adolescent males involved in the juvenile justice system after their time in a rehabilitation facility or community detention in their area of residence. Although evaluation studies are typically conducted using quantitative research methods, we believe a narrative research approach can be a useful methodology that elucidates “ why” and “ how” (...) or “ the story” behind the success of the program. As such, we evaluated the effectiveness of the MHAP in facilitating the reintegration of its beneficiaries through the stories they tell. Particularly, we analyzed and compared the life stories of MHAP beneficiaries who have been successfully reintegrated into their respective communities within the frame of redemptive narrative identity. The analysis of the interview data revealed that the life stories of these former beneficiaries contained redemption scenes in which they drew on adverse childhood experiences (extreme poverty, parental neglect, abuse, abandonment, and crime) in realizing their true selves (by gaining wisdom from the past, opportunities, new sources of strength, and desire to help others). Importantly, the redemption narratives also contained key life episodes that recognized the MHAP as the key to their successful reintegration into society. Such findings provide valuable information (i.e. how the program has achieved its objectives) to all levels of the MHAP, from program beneficiaries and front-line staff to decision-makers and funders, as well as community partners. (shrink)

Increasingly, clinical research is evaluated on the quality of its statistical analysis. Traditionally, statistical analyses in clinical research have been carried out from a ‘frequentist’ perspective. The presence of an alternative paradigm – the Bayesian paradigm – has been relatively unknown in clinical research until recently. There is currently a growing interest in the use of Bayesian statistics in health care research. This is due both to a growing realization of the limitations of frequentist methods and to the ability of (...) Bayesian methods explicitly to incorporate prior expert knowledge and belief into the analyses. This is in contrast to frequentist methods, where prior experience and beliefs tend to be incorporated into the analyses in an ad hoc fashion. This paper outlines the frequentist and Bayesian paradigms. Acute myocardial infarction mortality data are then analysed from both a Bayesian and a frequentist perspective. In some analyses, the two methods are seen to produce comparable results; in others, they produce different results. It is noted that in this example, there are clinically relevant questions that are more easily addressed from a Bayesian perspective. Finally, areas in clinical research where Bayesian ideas are increasingly common are highlighted. (shrink)

Philosophy of Communication Ethics is a unique and timely volume that creatively examines communication ethics, philosophy of communication, and "the other.".

Our capabilities in space are growing almost as fast as our ambitions. Many nations, companies, and private actors are currently vying to secure historic “firsts” in space, raising complex social and ethical questions. There is surprisingly little serious analysis of these issues, however, and they are rarely discussed in undergraduate class discussions, despite their popularity with students. To help correct this deficit, a student research team designed 11 case studies to help instructors across the curriculum introduce space into their classes. (...) These are designed for ease of use, with self-contained background information, suggested readings/movies, and a series of juicy questions. (shrink)

This paper is written in an analytic style, but it is meant to deprive analysis of an important prop. The title needs a short introduction. The mistake is to take ‘real’ as governed in its separate uses by criteria; and this paper is meant to show that this is a mistake and that Ausin makes it. In the course of the argument I try to develop my own account and, although I am not altogether satisfied with it, the result gives (...) something to build upon. I believe the mistake is by no means confined to Austin, but that it is connected with a particular conception of philosophy. (shrink)

The majority of healthcare professionals regularly witness fragility, suffering, pain and death in their professional lives. Such experiences may increase the risk of burnout and compassion fatigue, especially if they are without self-awareness and a healthy work environment. Acquiring a deeper understanding of vulnerability inherent to their professional work will be of crucial importance to face these risks. From a relational ethics perspective, the role of the team is critical in the development of professional values which can help to cope (...) with the inherent vulnerability of healthcare professionals. The focus of this paper is the role of Communities of Practice as a source of resilience, since they can create a reflective space for recognising and sharing their experiences of vulnerability that arises as part of their work. This shared knowledge can be a source of strength while simultaneously increasing the confidence and resilience of the healthcare team. (shrink)

Pragmatic randomized controlled trials are designed to evaluate the effectiveness of interventions in real-world clinical conditions. However, these studies raise ethical issues for researchers and regulators. Our objective is to identify a list of key ethical issues in pragmatic RCTs and highlight gaps in the ethics literature. We conducted a scoping review of articles addressing ethical aspects of pragmatic RCTs. After applying the search strategy and eligibility criteria, 36 articles were included and reviewed using content analysis. Our review identified four (...) major themes: 1) the research-practice distinction; 2) the need for consent; 3) elements that must be disclosed in the consent process; and 4) appropriate oversight by research ethics committees. 1) Most authors reject the need for a research-practice distinction in pragmatic RCTs. They argue that the distinction rests on the presumptions that research participation offers patients less benefit and greater risk than clinical practice, but neither is true in the case of pragmatic RCTs. 2) Most authors further conclude that pragmatic RCTs may proceed without informed consent or with simplified consent procedures when risks are low and consent is infeasible. 3) Authors who endorse the need for consent assert that information need only be disclosed when research participation poses incremental risks compared to clinical practice. Authors disagree as to whether randomization must be disclosed. 4) Finally, all authors view regulatory oversight as burdensome and a practical impediment to the conduct of pragmatic RCTs, and argue that oversight procedures ought to be streamlined when risks to participants are low. The current ethical discussion is framed by the assumption that the function of research oversight is to protect participants from risk. As pragmatic RCTs commonly involve usual care interventions, the risks may be minimal. This leads many to reject the research-practice distinction and question the need for informed consent. But the function of oversight should be understood broadly as protecting the liberty and welfare interest of participants and promoting public trust in research. This understanding, we suggest, will focus discussion on questions about appropriate ethical review for pragmatic RCTs. (shrink)

Mixed lineage leukemia (MLL) fusion protein (FP)‐induced acute leukemia is highly aggressive and often refractory to therapy. Recent progress in the field has unraveled novel mechanisms and targets to combat this disease. Menin, a nuclear protein, interacts with wild‐type (WT) MLL, MLL‐FPs, and other partners such as the chromatin‐associated protein LEDGF and the transcription factor C‐Myb to promote leukemogenesis. The newly solved co‐crystal structure illustrating the menin–MLL interaction, coupled with the role of menin in recruiting both WT MLL and MLL‐FPs (...) to target genes, highlights menin as a scaffold protein and a central hub controlling this type of leukemia. The menin/WT MLL/MLL‐FP hub may also cooperate with several signaling pathways, including Wnt, GSK3, and bromodomain‐containing Brd4‐related pathways to sustain MLL‐FP‐induced leukemogenesis, revealing new therapeutic targets to improve the treatment of MLL‐FP leukemias. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Ethics of Revenge and the Meanings of the Odyssey by Alexander C. LoneyEmily P. AustinAlexander C. Loney. The Ethics of Revenge and the Meanings of the Odyssey. New York: Oxford University Press, 2019. Pp. xii +265. Hardcover, $78.00. ISBN 978-0-190-90967-3.The Ethics of Revenge and the Meanings of the Odyssey places Odysseus' climactic act of revenge where it belongs: at the center of our interpretation of the Odyssey. (...) With admirably clear prose, Loney traces out the recurring pattern of tisis narratives woven through the poem. The accumulation of these revenge stories demonstrates that, in Loney's words, "tisis breeds endless further plots, making an epic of revenge fatally open-ended" (225, emphasis mine). Although the focus is simple, Loney's comprehensive account of the workings of revenge narratives commands the reader's interest. I, for one, was unprepared to recognize how systematically the poet sets up its readers to be disturbed by the ending—although I have long found the final books of the Odyssey troubling. On Loney's reading, the Odyssey sets up the terms of revenge's justice such that, on those very terms, the execution of vengeance is always ambivalent. For anyone with interests in Homer or revenge narratives, Loney's book has much to offer.The Ethics of Revenge begins with archaic conceptions of vengeance (tisis) (chap. 1). Loney distinguishes between "positive" reciprocity, which aims at balance through the ostensibly free exchange of benefits; and "negative" reciprocity, which is blatantly transactional: tisis is a form of negative reciprocity, where harm is met with immediate and (supposedly) equivalent harm. But as Loney shows, the returning harm is equivalent to the initial harm only insofar as someone judges it to be so. This insight is essential to understanding the inconclusive quality of vengeance: one person's retributive act is, potentially, another person's harm received. The justice achieved by such retributions is limited to the perspective of the one judging.Loney turns to such overlapping stories of tisis in the Odyssey in chapter 2. These overlaps prime the audience to notice ethical complexities among different characters' claims about wrongdoings and merited punishments. For Loney, Zeus' story of Orestes in Book 1 is the paradigmatic tisis narrative of the Odyssey. From this story, Loney distills the elements of all tisis narratives in the poem: absence (Agamemnon away) → unheeded warning / recklessness (Aigisthos ignores Hermes' warning) → preparation for offense (Aigisthos woos Klytaimnestra) → offense (Aigisthos commits adultery with Klytaimnestra and murders Agamemnon) → preparation for retribution (Orestes returns to Mycenae) → retributive act (Orestes kills Aigisthos and Klytaimnestra) → just order restored (Aigisthos has repaid in full). [End Page 535] Loney emphasizes how the unheeded warnings contribute to the ideal of immediate equivalence in tisis: when an offender chooses to perpetrate harm despite a warning (often marked by the term ἀτασθαλίαι), he or she effectively chooses to suffer retribution. The narrator of the tisis story moreover stresses equivalence—in the Orestes paradigm, killing for killing.In the next four chapters, Loney masterfully applies this theoretical and philological work to his interpretation of the poem. Chapter 3 follows three narratives of divine vengeance: Zeus avenging the companions' offense against Helios; Poseidon avenging Odysseus' blinding of Polyphemos; and Poseidon taking vengeance on the Phaiakians, who helped Odysseus. With clear analysis of story patterns and intratextual resonance, Loney shows how these stories evoke latent meanings through their parallels, echoes, or mutual implications. So, for example, Odysseus complicates the narrative of Poseidon avenging Polyphemos with his own story of Polyphemos' wrongs against him and his companions; and the vengeance of Poseidon on the Phaiakians is left literally open-ended, with the poet never telling us if Zeus destroys the island or not. As a result, by the time we get to the central tisis narrative of the poem (chap. 4), Odysseus' vengeance against the suitors comes to us against a varied backdrop of inconclusive and intertwined stories of retribution.In chapter 4, Loney explicates the key aspects of tisis in Odysseus' "terrifying revenge" (cf. Plato's Ion 535c7). For example, the suitors receive five of the poem's nine attributions of ἀτασθαλίαι, marking their wrongdoings as "precipitating harm" that... (shrink)

Background Pragmatic randomized controlled trials are designed to evaluate the effectiveness of interventions in real-world clinical conditions. However, these studies raise ethical issues for researchers and regulators. Our objective is to identify a list of key ethical issues in pragmatic RCTs and highlight gaps in the ethics literature. Methods We conducted a scoping review of articles addressing ethical aspects of pragmatic RCTs. After applying the search strategy and eligibility criteria, 36 articles were included and reviewed using content analysis. Results Our (...) review identified four major themes: 1) the research-practice distinction; 2) the need for consent; 3) elements that must be disclosed in the consent process; and 4) appropriate oversight by research ethics committees. 1) Most authors reject the need for a research-practice distinction in pragmatic RCTs. They argue that the distinction rests on the presumptions that research participation offers patients less benefit and greater risk than clinical practice, but neither is true in the case of pragmatic RCTs. 2) Most authors further conclude that pragmatic RCTs may proceed without informed consent or with simplified consent procedures when risks are low and consent is infeasible. 3) Authors who endorse the need for consent assert that information need only be disclosed when research participation poses incremental risks compared to clinical practice. Authors disagree as to whether randomization must be disclosed. 4) Finally, all authors view regulatory oversight as burdensome and a practical impediment to the conduct of pragmatic RCTs, and argue that oversight procedures ought to be streamlined when risks to participants are low. Conclusion The current ethical discussion is framed by the assumption that the function of research oversight is to protect participants from risk. As pragmatic RCTs commonly involve usual care interventions, the risks may be minimal. This leads many to reject the research-practice distinction and question the need for informed consent. But the function of oversight should be understood broadly as protecting the liberty and welfare interest of participants and promoting public trust in research. This understanding, we suggest, will focus discussion on questions about appropriate ethical review for pragmatic RCTs. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:56~ BOOK REVIEWS of the problem of free will and God's omnipotence- not a problem peculiar to evolution, to be sure, but one that nonetheless arises within the context of the emergence of living things, especially man, on earth and how that process relates to divine intervention; and Francisco J. Ayola starts everything off with a biologist's hardline defense of evolutionary theory. It may be asking too much to (...) expect original thinking on a topic that has been subjected to so much investigation and controversy over the past century. But it is reasonable to expect, in a book such as Evolution and Crea.tion, ways of approaching the topic which spark the reader's interest and furnish him with a competent and sometimes brilliant overview to it. The book fulfills this.expectation. I think it would be particularly useful as a source book and catalyst in graduate level seminars. University of San Francisco San Francisco, California RAYMOND DENNEHY God and Nature: Historical Essays on the Encounter Between Chris·tianity and Science. Edited by DAVID C. LINDBERG and RONALD L. NUMBERS. Berkeley and Los Angeles: University of California Press, 1986. Pp. xi + 516. $50.00 (cloth), $17.95 (paper). The editors tell us at the outset of this important volume that it is the outcome of two convictions that they share: (1) "that the interaction of science and Christianity has been of profound imp@tance in the shaping of Western civilization" and (2) that the results of extensive specialist work by historians of science and religion in recent decades belie widelyheld stereotypes and ought to be made generally available. The most familiar of the stereotypes is of course the Draper-White 66 warfare" thesis, the origins and continuing influence of which the editors trace in the first part of their helpful introduction. The eighteen contributors to the volume find plenty of controversies-sometimes rising to the level of conflicts-among individuals, among theological schools of thought, among scientific schools of thought, and among social groups, but at no period do they find anything that could be called an overall conflict of science and theology. They find many instances of smallerand larger-scale influences of theological developments on scientific ones, of scientific developments on theological ones, and of social developments on both. But no grand overall interpretative scheme appears in this respect either. Stanley L. Jaki's thesis, for instance, that modern science BOOK REVIEWS 563 was born of Christian theology and has prospered just insofar as it has remained faithful to its parentage, fares no better than the warfare thesis. No sweeping unitary interpretation can be expected to emerge, Lindberg and Numbers sugg.est, from historical work that " shows the respect for the particularity, individuality and value of each people and age that the canons of historical scholarship demand" (p. 10; i:r).ternal quotation from Donald Kagan). Accordingly, each essay is devoted to a particular period-some longer than others, to be sure. Nearly all are by professional historians. One author is primarily a philosopher, and several have at least secondary philosophical interests ; none are primarily scientists or theologians. Nearly all were trained and teach at secular universities, though a few have formal training from religious institutions as well. The coverage by periods is comprehensive, from Lindberg on " Science and the Early Church" to Numbers on "The Creationists" and Keith Yandell (the philosopher) on "Protestant Theology and Natural Science in the Twentieth Century." The last title calls attention, however, to one oddity in the coverage. Whereas in the essays on the sixteenth through eighteenth centuries both Protestant and Catholic figures and movements are treated, in those on the nineteenth and twentieth centuries attention is focused almost exclusively on the Protestant scene. Clearly, eighteen substantial essays cannot be analyzed in detail in a review of reasonable length. I shall indicate the main topics and theses of each with a few comments where these can be made briefly. First, however, I should stress that the book is treasure-trove of information and ideas. All the essays are good; several are superb. Each should be highly instructive for readers who are not specialists in the topic and period it deals with... (shrink)

The Oxford or Tractarian Movement and later Ritualists and Anglo-Catholics schooled numerous converts in elements of the Catholic faith. Foremost among them was John Henry Cardinal Newman, one of the original founders of the Oxford Movement. Converts numbered in the hundreds and included another cardinal, Henry Edward Manning, the second Archbishop of Westminster, the religious foundress Cornelia Connelly, the priest novelist Robert Hugh Benson and later literary figures such as G.K. Chesterton, Evelyn Waugh and Mgr Ronald Knox. American historian, Patrick (...) Allitt, has argued that on both sides of the Atlantic converts dominated Catholic intellectual life between 1840 and 1960. While such 'Tractarian' converts have indeed greatly influenced Catholic life, many 'Tractarians' who never converted have also had a considerable impact on English-speaking Catholicism. C.S. Lewis is an obvious example. But there have been others, including author Charles Williams, poet T.S. Eliot and theologians John Macquarrie and Michael Ramsey. The author Dorothy L. Sayers also deserves to be counted among their number. (shrink)

The word ‘tyrant’ was not originally Greek, but borrowed from some eastern language, perhaps in western Asia Minor. On the other hand, tyranny as it developed in the Greek cities in the archaic age would seem to have been initially an indigenous growth, independent of any intervention by foreign powers. It then became a constantly recurring phenomenon of Greek political and social life, so long as the Greeks enjoyed an independent history.

The word ‘tyrant’ was not originally Greek, but borrowed from some eastern language, perhaps in western Asia Minor. On the other hand, tyranny as it developed in the Greek cities in the archaic age would seem to have been initially an indigenous growth, independent of any intervention by foreign powers. It then became a constantly recurring phenomenon of Greek political and social life, so long as the Greeks enjoyed an independent history.

Alle Formen von Leben entstanden aus der primitiven Zelle, betrachtet eher als eine Art denn als ein Individuum, welches die Fähigkeit für ununterbrochene Selbst-Teilung besass. Fortgesetzte Vermehrung der Zellen mag eins von drei verschiedenen Verfahren folgen: 1. Die zwei Zellen von jeder Teilung hervorgehend, mögen sich vollständig von einander trennen; diese Linie der Entwicklung der primitiven Zelle rief die Protozoa hervor. 2. Während die Zellen sich teilen, mögen sie mehr oder weniger unregelmässig zusammen hängen. Diese Linie rief die Porifera hervor. (...) 3. Die sich teilenden Zellen mögen regelmässig zusammenhängen, eine Blastula und eine Gastrula bildend. Die Gastrula ist fähig eine unbestimmte Anzahl von Variationen hervorzubringen, und durch diese Variationen in der Gastrula entstanden alle Tier-Typen ausser der Protozoa und der Porifera.Diese Linien der Entwicklung von der einzelnen Zelle stellen alle die physischen und geometrischen entfaltungsfähigen Möglichkeiten, denkbar im Falle von Zellen, dar, die die Kraft besitzen sich durch Selbst-Teilung zu vermehren. Da diese entfaltungsfähigen Linien einfach mechanische Antworten auf die geometrischen und physischen Eigentümlichkeiten sind, eigen der Vermehrung der sich selbst teilenden Zellen, so gibt es keine Rechtfertigung für die Annahme einer bestimmten Ordnung in ihrem Vorkommen. Es ist logischer anzunehmen, dass die primitive Zelle gleich nach ihrem Erscheinen sich nach jeder möglichen Richtung gleichzeitig entwickelte, kurz, dass alle die Haupttypen des Tierlebens gleichzeitig erschienen.Es gibt keinen Beweis gegen diese Annahme, welche in Übereinstimmung mit dem geologischen Hintergrund des Lebens ist, wie wir es verstehen; mit der Fossilien-Urkunde, wie illustriert durch Fossilien von genau vergleichbaren Umgebungen; und mit der angenommenen Nötigkeit für ein System von Kontrolle und Ausgleich zwischen den verschiedenen Typen von Leben.Toutes les formes de la vie proviennent d'une cellule primitive unique, considérée comme espèce plutôt que comme individu, possédant le pouvoir de se multiplier par bi-partition répétée. La propagation continue de cellules peut avoir lieu de trois façons différentes: 1. Les deux cellules, après la division, peuvent se séparer complètement l'une de l'autre; cette forme de propagation de la cellule primitive a donné lieu aux Protozoaires. 2. Les cellules, en se divisant, peuvent rester liées plus ou moins irrégulièrement; cette forme de propagation caractérise les Porifères . 3. Les cellules, en se divisant, peuvent rester liées selon un arrangement régulier, en formant une blastula et une gastrula; la gastrula peut être formée selon un infinité de modalités, et c'est à ces différences de la formation de la gastrula que sont dues toutes les espèces animales exceptés les Protozoaires et les spongiées.Ces formes de propagation de la cellule unique représentent la somme des possibilités d'arrangement permises par les lois de la géométrie et de la physique. Du moment que ces procédés de propagation sont soumis à un arrangement mécanique gouverné par des lois physiques et géométriques, il n'y a pas lieu d'admettre qu'il y ait, dans leur succession, d'ordre déterminé. Il est plus logique de supposer qu'aussitôt parue la cellule primitive se soit propager simutanément dans toutes les directions concevables, en d'autres mots que toutes les phyla animales se soient différenciées au même moment.Aucune preuve ne démont cette hypothèse qui, d'ailleurs, concorde avec les prémises géologiques de la vie telles que nous les comprenons, avec les vestiges fossilisés de couches géologiques strictément comparable, et avec la théorie qui admet l'établissement de l'équilibre entre les différentes espèces animales au moyen d'un contrôle et de limitations mutuelles. (shrink)

The fundamental problem on which Ilya Prigogine and the Brussels–Austin Group have focused can be stated briefly as follows. Our observations indicate that there is an arrow of time in our experience of the world (e.g., decay of unstable radioactive atoms like uranium, or the mixing of cream in coffee). Most of the fundamental equations of physics are time reversible, however, presenting an apparent conflict between our theoretical descriptions and experimental observations. Many have thought that the observed arrow of (...) time was either an artifact of our observations or due to very special initial conditions. An alternative approach, followed by the Brussels–Austin Group, is to consider the observed direction of time to be a basic physical phenomenon due to the dynamics of physical systems. This essay focuses mainly on recent developments in the Brussels–Austin Group after the mid-1980s. The fundamental concerns are the same as in their earlier approaches (subdynamics, similarity transformations), but the contemporary approach utilizes rigged Hilbert space (whereas the older approaches used Hilbert space). While the emphasis on nonequilibrium statistical mechanics remains the same, their more recent approach addresses the physical features of large Poincare systems, nonlinear dynamics and the mathematical tools necessary to analyze them. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

In Living for Pleasure, philosopher Emily Austin offers a lively, jargon-free tour of Epicurean strategies for diminishing anxiety, achieving satisfaction, and relishing joys.